| Signatura : | Biblioteca OET: S10685. NBINA-1860. |
| Autor : | Brady, Sean F; Singh, Maya P; Janso, Jeffrey E; Clardy, J. |
| Dirección : | Cornell University, Department of Chemistry & Chemical Biology, Ithaca, NY 14853, US E-mail: sfb3@cornell.edu E-mail: jon_clardy@hms.harvard.edu. |
| Título: |
Cytoskyrins A and B, new BIA active bisanthraquinones isolated from an endophytic fungus. |
| P.imprenta: | v. 2, no. 25, p. 4047-4049. Año 2000. |
| Serie: | Organic Letters. |
| Descriptores: | EUMYCOTA; DEUTEROMYCOTINA; DIAPORTHALES; ASCOMYCOTA; FUNGI.
CYTOSPORA; CYTOSPORONES; BIOCHEMICAL INDUCTION ASSAY; DNA DAMAGE COMPOUNDS; DNA SYNTHESIS INHIBITION; NATURAL PRODUCTS; ANTICANCER AGENTS; BISANTHRAQUINONES; 1,3,6,8-TETRAHYDROXYANTHRAQUINONE; ENDOPHYTIC FUNGUS; CYTOSKYRIN A; CYTOSKYRIN B; PLANT PROSPECTION; CHEMICAL PROSPECTION; BIOLOGICAL ACTIVITY.
COSTA RICA; CENTRAL AMERICA.
INBIO; AREA DE CONSERVACION GUANACASTE.
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| Resumen: | The biochemical induction assay (BIA) is a rapid (colorimetric) bacterial assay used to identify compounds that damage DNA or inhibit DNA synthesis and thereby identify potential natural product anticancer agents. Bisanthraquinones based on a 1,3,6,8-tetrahydroxyanthraquinone-type carbon skeleton were isolated from an endophytic fungus and characterized by NMR and X-ray crystallography. Cytoskyrin A (1) is highly active in the biochemical induction assay, while the closely related cytoskyrin B (2) has no detectable activity in this assay |